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A sensitive and specific assay for aldosterone is therefore needed to monitor adrenocortical activity in murine studies of renal function and cardiovascular diseases.
Previous murine studies of vaccination and challenge with influenza have shown that cellular immune responses can provide protection from infection-associated morbidity and mortality [25], [26], [27], [28].
As a result of this difference, it has been argued that conclusions drawn from murine studies of CpG might be difficult to translate to human clinical trials.
In murine studies of sepsis, an important role for CD80 and CD86 antigens in the response to sepsis has been established [ 29, 30].
12 Thus, it appears that GFAP-Cre does not target HSCs exclusively and its overall utility in murine studies of liver disease has still to be fully clarified.
In vivo murine studies of Gd ⋅1 have shown accumulation of the probe in the pancreas with increased signal intensity over 140 minutes.
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In addition, the ability of murine studies to predict the quantitative and qualitative human toxicology of cancer therapeutics was studied.
Our results as first reported in Kallestrup et al., (2005) [ 7], further question the applicability of murine studies that show a dependency of adequate CD4 cell immunity for S. mansoni development and fecundity to human conditions.
In contrast to murine studies, the role of synoviolin in human RA is less well understood.
Helicobacter pylori upregulate Toll-like receptor 4 (TLR4) [49], and although results are complex, human and murine studies suggest that activation of TLR4 may be protective against allergic asthma [50].
This is further supported by murine studies showing that administration of a Pam3CSK4 with OVA augmented Th2-associated cytokine production by antigen-specific T cells [35].
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