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After either subcutaneous or intravenous injection, these QDs were used as angiographic contrast agents for vessels surrounding and penetrating murine squamous cell carcinoma in mice.
A murine squamous cell carcinoma model was used to test whether blood and lymphatic vessel triads are also a feature of more slowly growing spontaneous tumors.
The study was originally set up to measure accurate cell kinetic parameters in two murine squamous cell carcinomas (scc) for comparison with radiobiological data on proliferation during radiotherapy.
On the other hand, "tumor-associated matrices" were obtained from one, out of four different fibroblastic cell lines, isolated from advanced ("late") two-staged chemical carcinogenic-induced murine squamous cell carcinomas [ 44].
Importantly, transcripts upregulated by Hras G12V in our primary keratinocytes strongly and significantly overlapped with the putative cancer stem cell signatures obtained from murine squamous cell carcinoma (SCC) models (Schober and Fuchs, 2011).
Studies in pancreatic cell lines (Lawrence et al, 1996), and in murine squamous cell carcinoma models (Fields et al, 2000), have confirmed that minimal cytotoxic doses are required for radiosensitivity and which persists for 48 h after administration.
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Similar experiments with the murine SCCVII squamous cell carcinoma suggested that hydroethidine might be a useful indirect stain for locating hypoxic cells in experimental tumours when used in combination with a perfusion probe such as Hoechst 33342.
The ability of the dual-function bioreductive drug, RSU 1069, to identify hypoxic cells in multicell spheroids and murine SCCVII squamous cell carcinomas was examined using the alkaline comet method.
Similarly, the overproduction of active recombinant cystatin C resulted in a pronounced reduction in Matrigel invasion of murine squamous carcinoma cells (Coulibaly et al, 1999).
For instance, the injection of antisense to the p65 subunit of NF- κB inhibited the growth of murine fibrosarcoma in vivo (Higgins et al, 1993) or murine and human squamous cell carcinomas, in vitro (Duffey et al, 1999; van Hogerlinden et al, 1999).
For example, blockade of NF-κB predisposes murine skin to squamous cell carcinoma [ 7].
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