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We then generated a conditional KO mouse model to assess the function of miR-203 in murine skin development and carcinogenesis in vivo.
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Based on these reports, our laboratory has been investigating the effect of EP4 overexpression on murine skin tumor development.
Moreover, a tumor suppression function for alphav integrins appears to also exist in epithelial cells since the genetic ablation of alphav integrin gene in epithelial cells of murine skin leads to development of squamous cell carcinomas [64].
Here, we investigated whether TCDD altered the composition of lipids in developing murine skin.
By crossing LSL-K-RasG12D mice with those expressing a Cre-estrogen receptor (Cre:ER) fusion protein under the transcriptional regulation of the Cytokeratin 14 (K14) promoter, mutant K-RasG12D expression was induced in murine skin, which resulted in highly penetrant and rapid development of benign hyperplastic oral papillomas.
Oncogenic mutation of the Hras gene is one of the initiating drivers in the development of benign papillomas and malignant squamous cell carcinomas in murine skin chemical carcinogenesis.
The conditional overexpression of ROCK2 in murine skin increased tissue stiffness and thickening and enhanced tumor incidence, growth, and progression.
We performed a fully MHC-mismatched murine skin allograft model69.
Shen, W. et al. Adaptive immunity to murine skin commensals.
Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin.
Here we show CD103+ DCs are the major do-DC subset involved in the acute rejection of murine skin transplants.
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