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These findings demonstrate that the murine response to scrapie infection in lymph nodes exhibits significant similarities to that demonstrated by ovine lymph nodes.
The probe sets clustered into six groups (Figure 1B) and these groups defined the gene expression cartography of the murine response to pneumonia (Figure 1C).
Thus, NS3/4A modulates the innate murine response to dsRNA in vivo.
Thus, one cannot characterize a general murine response to a high fat diet for hepatic expression using any specific strain, such as C57BL/6J.
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In this study, we determined the onset of visual deficits in a mouse model of progressive retinal degeneration (Pde6b− mice; Pde6b+ mice have normal vision) by observing murine responses to a visual task throughout development, from postnatal day (PND) 21 to adult (N = 174 reliable observations).
Based on cationic liposomes and including a synthetic mycobacterial glycolipid as TLR-independent immunomodulator, it induces strong and protective T helper-1 and T helper-17 adult murine responses to Ag85B-ESAT-6, a major mycobacterial fusion protein.
The species difference in response to LPS may contribute to the apparent disconnect between human and murine responses to LPS and may partially explain the difficulties of translating therapeutic interventions into clinical human sepsis.
We first screened the yeast library displaying the H1N1 HA peptides to study the murine immune response to recombinant HA protein of the 2009 A(H1N1) Influenza virus.
This study has demonstrated the effect of APAP on the murine hepatic response to IFN-β in vivo using a whole genome microarray.
We conclude that the interaction of HSV gD with HVEM may alter early innate events in the murine immune response to infection, without significantly affecting acute mortality, morbidity, or initial T-cell responses after lethal challenge.
The functional categories of host genes most affected by Mtb infection included innate immune response, T cell activation, antimicrobial response, apoptosis and metabolism, based on analysis by Pathway Express (Figure 3B), consistent with a previously published study of the murine transcriptional response to Mtb [33].
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