Sentence examples for murine prostate stem from inspiring English sources

Murine prostate stem cell antigen.

The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer.

In this study, we demonstrated that murine prostate epithelial stem cells are indeed susceptible to dissociation-induced apoptosis.

Given the reported similarity between murine breast and prostate stem cells (Lawson et al, 2007) and the recent identification of a CD44+CD24− subpopulation of breast cancer cells that have an increased tumorigenic capacity (Al-Hajj et al, 2003), we sought to identify and characterise CD44+CD24− cells in human prostate cell lines.

Transgenic expression of activated AKT1 in the murine prostate induces prostatic intraepithelial neoplasia (PIN) that does not progress to invasive prostate cancer (CaP).

CD45− CD31− Ter119− Sca-1+ CD49f+ enriched cells localised to the basal layer within the proximal region of the prostate after injection suggesting that this is the endogenous location of stem cells in the murine prostate.

Both prostate carcinoma and benign prostatic hypertrophy are considered to arise from the aberrant proliferation of prostate stem cells.

In addition, prostate cancer expresses numerous TAAs which include the Prostate Specific Antigen (PSA) [11, 12], Prostatic Acid Phosphatase (PAP) [13], Prostate Specific Membrane Antigen (PSMA) [12, 14], Prostate Stem Cell Antigen (PSCA) [15] and Six Transmembrane Epithelial Antigen of the Prostate (STEAP) [16].

Murine prostate specific membrane antigen.

Adult prostate stem cell biology is highly analogous to the biology of the developing prostate from embryonic prostate stem cells, and understanding the pathways that govern normal prostate development lends insight into the pathways that maintain adult prostate stem cells and prostate cancer stem/progenitor cells.

Recent studies have implicated the tumor microenvironment in prostate tumorigenesis and have identified putative prostate stem cells in adult tissue.