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In addition, low cost, ease of handling, known genetics, a well-defined immune system, and controllable oral microflora favor murine over other animal species in periodontal studies [ 27, 28].
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The potent effects of S1P on GC-B signaling are not confined to the immortalized murine fibroblasts over-expressing GC-B in the above studies.
In vivo analysis of murine fibroblasts over-expressing full-length MeCP2[T158M] indicated defective binding to heterochromatic foci, and FRAP analysis showed greater mobility of MeCP2[T158M] compared with WT protein, indicating a less stable association with chromatin (25, 26).
We adapted a recently developed AFM-based nano-rheology system to probe the dynamic nanomechanical properties of murine cartilage over a wide frequency range of 1 Hz to 10 kHz, and studied the role of glycosaminoglycan (GAG) on the dynamic modulus and poroelastic properties of murine femoral cartilage.
The overall popularity of the Affymetrix Mouse Genome 430.2 platform across many murine studies (over 1400 experimental series in GEO, (GPL: 1261)) and within the GUDMAP consortium [35], lead to the creation of a riboprobe primer design tool (http://uqgudmap.imb.uq.edu.au/riboprobe_design/).
There was an increase in the percentage of donor cell mtDNA between reconstruction and the 2-cell stage, which was not significant (p>0.05), but represented approximately a 5-fold increase in murine mtDNA over the donor MEF contribution (50±4.3 copies of mtDNA per cell).
The immunoreactivity of the humanised HMFG1 was found to be similar to the murine of over 90%.
To obtain an unbiased value of the protective effect of losartan, we measured the reduction of the two most pronounced toes on the murine forepaw over time.
Our understanding of the pathogenesis mechanisms leading to lupus has been augmented by the analysis of several different murine models over the past four decades.
Use of this system to excise and inactivate genes of interest by looping out the DNA between two parallel loxP sites on exposure to regulated Cre expression was first demonstrated in murine cells over a decage ago [ 47].
Species selectivity of DMXAA (5,6-dimethylxanthenone-4-acetic acid, Vadimezan) for murine cells over human cells could explain in part the recent disappointing phase III trials clinical results when preclinical studies were so promising.
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