Sentence examples for murine models when from inspiring English sources

They also illustrate the need for researchers to be careful when choosing among murine models when planning to study SCA3 disease pathogenesis.

The higher expression of phenotypic characteristics related to virulence by S. brasiliensis can explain its higher virulence in murine models, when compared to S. schenckii [ 32].

To improve the immunogenicity of the five-plasmid mixture, a sixth plasmid encoding human granulocyte macrophage-colony stimulating factor (hGM-CSF) was added, based on enhanced protection in murine models when a plasmid encoding murine GM-CSF was combined with other plasmids encoding malaria antigens.

In tolerogenic DC-based therapies, immature, maturation-resistant, or alternatively-activated DC are generated in vitro by different culture, pharmacologic or genetic methods and then administered i.v. into graft recipients, with optimal results in murine models when the DC are administered 7 days prior to transplantation.

In a murine model, when attenuated S19 and virulent 2308 strains were compared to genetically engineered strains, including: (1) a knock-out mutant of 2308 (ΔeryCD), (2) a naturally reverted S19 strain (ery resistant), and (3) strainrain transformed with the wild type ery operon, there was no direct correlation between erythritol metabolism and in vivo colonization [18].

We have previously suggested a combination antibiotic-antitoxin approach to anthrax therapy and for the first time demonstrated an increased efficacy of ciprofloxacin treatment in a murine model when it was combined with a caspase inhibitor administration [ 22].

Ribeiro et al. [ 12] described a high protection rate (80%) in a murine model when using an iron acquisition-deficient mutant obtained with the same methodology employed to develop the CP09 mutant, showing that C. pseudotuberculosis live attenuated mutants can be promising tools for protection against caseous lymphadenitis.

Inhibition or genetic ablation of DPPIV/CD26 showed promising engraftment-promoting effects in several murine models especially when limited numbers of donor cells were used [25].

The preclinical findings described offer evidence that the combination of CTLA-4 blockade with various chemotherapeutic agents that exhibit different mechanisms of action, including ixabepilone, paclitaxel, etoposide, and gemcitabine, elicited synergistic antitumor activity in murine tumor models when administered concurrently.

IL-18 has shown to have anti-tumor effects in several murine tumor models when transferred into tumor cells, alone [ 12- 14] or in combination with IL-12 [ 15] or IL-23 [ 16].

Furthermore, Holstein and Hohl (2001b) demonstrated synergism between paclitaxel and lovastatin on human cancer cell lines, whereas Feleszko et al (2002) showed an in vivo enhanced antitumour activity of doxorubicin in murine tumour models when associated with lovastatin.