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Adoptive transfer of these TILs to murine models was shown to lead to regression in lung and liver tumors (Rosenberg et al., 1986).
The correlation of high RANK expression with osteotropism in murine models was demonstrated across diverse tumor cell types, including breast cancer and melanoma [29].
The correlation of high RANK expression with osteotropism in murine models was demonstrated across diverse tumour cell types, including breast cancer and melanoma [ 8].
28 31 In the case of otelixizumab (non-FcR-binding anti-CD3), experience from murine models was combined with limited human data to arrive at a dose.
The profile of the immune response elicited by adenovirus vaccines against tumor antigens in murine models was investigated by some research groups (see [ 15- 17]).
Ablation of TBX20 in murine models was independently generated by three research groups and showed similar phenotypic features [ 16, 75, 79].
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Murine models are commonly used to investigate bone healing and test new treatments before human trials.
While murine models are powerful tools to study pregnancy and maternal-fetal immune interactions, in contrast to human placental exosomes, the content of murine placental and pregnancy exosomes remains largely understudied.
Murine models are useful tools to study lymphomagenesis and disease progression, as well as potential treatment in a pre-clinical setting.
From 1950s to 1970s syngeneic murine models were used.
This point is essential since although murine models are very different from humans due to their own evolutionary specificities, when it comes to shock or its treatment, the persistence of fundamental responses shared by all mammals must be acknowledged.
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