To that end, we developed a surrogate LASV murine model utilizing rVSV-GPC (Supplementary Fig. 4), since LASV is a BSL-4 agent with no established LASV murine model.
To obtain transcriptome information from bacteria colonizing the murine GI tract, we initiated the murine model utilizing the P. aeruginosa PAK strain.
An in vivo murine model utilizing Ba/F3-JAK2V617F ascitumorsmors was developed as a FACS-based surrogate system with ready access to tumor cells for use in understanding the correlation between pharmacodynamics and PK of JAK2 inhibition.
We used a murine model utilizing the CT26 colon cancer cell line to analyze primary and memory tumor-specific T-cell responses induced by an attenuated actin A and internalin B deleted immunodominant tumor-associated antigen expressing strain of Listeria monocytogenes for the treatment of metastatic colorectal cancer.
A number of murine models are utilized to study IPF and other human forms of pulmonary fibrosis in order to investigate disease progression and potential therapy.
We have developed animal models utilizing mice with severe combined immunodeficiency (SCID) which will accept human tumor cells or murine model systems of syngeneic and allogeneic transplantation.
To test this, we utilized an in vitro model utilizing murine cell lines in order to exclude the possibility of involvement of other cell types.
An inflammatory response associated with severe sepsis may be harmful, whereas the inflammatory response is necessary to clear infection, as demonstrated in an elegant murine cecal ligation and puncture model utilizing variable caliber of puncture.
Similarly, conflicting results have been reported utilizing murine models.
However, other studies also utilizing murine models of melanoma have found positive correlations between increased GM-CSF levels and growth of lesions 72.
