Sentence examples for murine models provide from inspiring English sources

Murine models provide a preclinical strategy to identify which combination of oncogenes are most likely to be effective [30], [52].

64– 67 Epigenetic studies in murine models provide key insight into the intergenerational transmission of PTB.

These in vitro and murine models provide some association [ 26, 32, 34– 37] and functional data [ 19, 20, 29, 33], but their utility as PDE biomarkers has yet to be established.

Evaluation of INC280 in combination with gemcitabine on tumour growth in these experimental murine models provide in vivo evidence that targeting cMET has potential that could be applied to improve outcomes in patients with pancreatic cancer.

Recent studies have demonstrated that the Ld gene product presents a number of immunodominant Toxoplasma gondii-derived peptides in the murine models, providing a paradigm for vaccine design.

Recent developments targeting the bromo and extraterminal (BET) subset of BRD proteins demonstrated remarkable efficacy in murine models providing a compelling rationale for drug development and translation to the clinic.

In addition, leukemia-initiating cells (LICs), which are responsible for relapse of leukemia, could be cleared by ATRA/ATO based treatment in murine models, providing further rationale of combined use of the two agents (Au et al., 2001, Ito et al., 2008, Nasr and de The, 2010, Nasr et al., 2008, Zhou et al., 2010).

It has recently been shown that the hepcidin-iron axis is a key component of innate immune defense against malarial superinfection in murine models, providing proof-of-principle for a likely wider role of hepcidin in protection against potentially lethal infections.

Further, the findings in murine model provide evidence for the importance of multi-functional CD4 Th1 response in protection against M. tuberculosis infection.

The defective pupillary light reflex of Bst+/– mice could be used as a convenient readout for quickly screening the effectiveness of stem cell therapies, a highly useful feature of this murine model providing a unique advantage over other systems.

Murine mouse models provide a range of customizable genotypes and phenotypes far superior to any other model organism.