Sentence examples for murine models lacking from inspiring English sources

Murine models lacking active GALNS do not successfully recapitulate the human skeletal disorder, as unlike the patients, they do not exhibit skeletal deformities, but do suffer from substrate accumulation in the brain [26], [27], [28].

Murine models, lacking vitamin D receptor, exhibit increased ventricular mass, higher atrial natriuretic peptides, and impaired homeostasis of metalloproteinases and fibroblasts, leading to ventricular dilatation and impaired electromechanical coupling [ 2].

To dissect the role of ROS in TB, different murine knockout models lacking active NADPH oxidase components have been generated and compared with the wild-type strain for their capability to control the growth of Mtb.

This murine model that lack the gene encoding apoE and LDL receptor knockout develop spontaneous hypercholesterolemia/hyperlipoproteinemia [ 19].

We are interested in understanding the role of IRF5 in human B cells since previous studies in mice implicated a role for IRF5 in effector B-cell development and function and murine models of lupus lacking the Irf5 gene showed reduced ANA, glomerulonephritis and pathogenic autoantibody production.

In a mouse knockout model lacking the murine homologue of human PTPN22 (PEST domain-enriched tyrosine phosphatase (PEP)), the threshold for T-cell receptor signalling was lowered and the number of effector and memory T-cells increased [ 17].

Several murine models with a partial lack of PPARγfunction have been generated and studied, including insulin-sensitive PPARγheterozygous mice.

The rsh null mutant showed altered morphology, reduced survival in synthetic minimal medium, strong attenuation in cellular and murine models of infection, and lack of induction of virB expression [ 23].

This is likely due to the lack of reliable experimental murine models reproducing various aspects of C. jejuni pathogenesis [11].

While the murine femoral artery ligation hind limb ischemia model lacks the component of occlusive proximal arterial disease found in humans, it is currently a standard small-animal model used to study the molecular biology of limb ischemia [18].

Murine models for BRCA1 and BRCA2 mutations have been stifled by the lack of phenotypes in the heterozygotes, and the early embryonic lethality of mice lacking both copies of BRCA1 or BRCA2 [ 3, 4].