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However, the use of murine models is restricted by costs, the requirement of specialized facilities and personnel, legal requirements and ethical considerations.

Previous experimental studies have suggested that inclusion of specific angiogenic chemokines in matrigel injected in vivo using murine models is able to promote a suitable microenvironment for recruitment of specific cell infiltrates [4], [16], [17].

Another marker, described to be indicative of stemness in MDB murine models, is CD15 [ 30].

Regardless of immune-mediated mechanism, the ultimate result of autoimmune hepatitis in humans and in murine models is hepatocyte death.

Therefore, the possibility to study not only cell lines, but also primary MM cells in murine models is relevant.

The impact of the lymphocyte dysfunction in murine models is independent of the other components of the immune system.

Murine models are commonly used to investigate bone healing and test new treatments before human trials.

While murine models are powerful tools to study pregnancy and maternal-fetal immune interactions, in contrast to human placental exosomes, the content of murine placental and pregnancy exosomes remains largely understudied.

Murine models are useful tools to study lymphomagenesis and disease progression, as well as potential treatment in a pre-clinical setting.

From 1950s to 1970s syngeneic murine models were used.

Adoptive transfer of these TILs to murine models was shown to lead to regression in lung and liver tumors (Rosenberg et al., 1986).