Paradoxically, one could have assumed that increased ERRα activity would be associated with the improvement of metabolic disorders; however, the results obtained in murine models indicate the opposite effect.
Studies in murine models indicate that cells of the innate immune system activated via their Toll-like receptors (TLR) can accelerate wound healing.
Multiple murine models indicate a pivotal role of IL-21 in the pathogenesis of autoimmune diseases [ 7- 9].
In vivo murine models indicate that gastrointestinal tract polyamine transport is mediated by endocytosis and solute carrier transport mechanisms (Pickhardt and Kim, 2009).
Interestingly, experimental murine models indicate that tumour cells in suspension, regardless of their numbers, are frequently unable to produce life-threatening cancer outgrowth, as opposed to solid tumour fragments (Ochsenbein et al, 2001), while inducing specific immune responses.
Murine models indicate that the function of CXCL13 CXCR5 interactions promotes recruitment of B cells and follicular T helper cells to the follicle and germinal centers in secondary lymphoid organs [ 19].
P140 K MGMT gene transfer in a murine model indicates significant resistance to the myelosuppressive effects of TMZ and O-BG (Sawai et al, 2001), and P140A MGMT protects haematopoietic cells against O-BG sensitisation to chloroethylnitrosourea treatment (Maze et al, 1999).
The analysis of a murine model indicated that this phenotype is associated with degeneration of hair cells, possibly due to cation overload.
Furthermore, a study in the murine model indicated that CpG achieved higher efficacy in the maturation of DCs when it was administered subcutaneously with tumor lysates.
Altogether, the observations in the murine model indicate that the induction of a multifunctional Th1 cell response by R/D regimen significantly contributes to the enhanced protection against M. tuberculosis infection.
