In addition, leukemia-initiating cells (LICs), which are responsible for relapse of leukemia, could be cleared by ATRA/ATO based treatment in murine models, providing further rationale of combined use of the two agents (Au et al., 2001, Ito et al., 2008, Nasr and de The, 2010, Nasr et al., 2008, Zhou et al., 2010).
Transfection studies of human HER2 cDNA into murine xenograft models further explored the role HER2 plays in tumor progression and metastasis.
Our aim was to generate an enhanced murine model to further elucidate the biological function of PANDER.
Murine models have allowed further exploration of the role of chemotherapy on the immune system.
Recent publications describing the successful use of new therapeutic agents in murine models support their further evaluation as therapies for SLE.
The associations found in humans and the empirical evidence from murine models suggest that further research into the immunmodulatory role of NK cells in autoimmunity is warranted and is likely to provide new insights into the pathogenesis of autoimmune disorders.
The associations found in humans and the empirical evidence from murine models demonstrate that further research into the immunomodulatory role of NK cells in autoimmunity is warranted and is likely to provide novel insights into the pathogenesis of autoimmune disorders.
Reports on MSCs for asthma therapy, available from murine models only (23, further discussed in the Supporting Information File), show that MSCs attenuate airway inflammation and hyperresponsiveness yet leave significant data gaps that should be addressed before any clinical trials can take place.
Of course, murine models remain valuable to further decipher the mechanisms of sepsis.
Further, in murine models of chronic pressure overload and diabetes, LXR agonism has been shown to oppose increases in myocardial fibrosis and pro-fibrotic gene expression in conjunction with improved diastolic function [ 17, 52].
