Sentence examples for murine models especially from inspiring English sources

Inhibition or genetic ablation of DPPIV/CD26 showed promising engraftment-promoting effects in several murine models especially when limited numbers of donor cells were used [25].

It will be interesting to determine whether downstream Hh pathway inhibitors are comparably active against murine tumor models, especially since Smo mutations that convey GDC-0449 resistance have been observed in mouse and human medulloblastomas upon drug treatment (43).

Even though the effect of estrogen on human lupus is still debatable, estrogen undoubtedly induces earlier onset of lupus and exacerbates lupus severity in murine lupus models, especially in NZB/WF1[ 33] 33].

These immunity patterns governing resistance or susceptibility to the fungus have been extensively demonstrated in murine models of infection, especially those comparing the course of the mycosis in A/Sn and B/10.A inbred mice, which mimic the polarized clinical forms of the human pcm [19].

As murine models demonstrate that especially DC are effective in inducing effective immune responses, ex vivo generated DC are currently applied to stimulate anti-tumour immunity in clinical trials (Banchereau et al, 2000; Coulie and van der Bruggen, 2003; De Vries et al, 2003; Schuler et al, 2003; Figdor et al, 2004).

- Rodent models, and especially murine models, offer many advantages over other species.

The PrPSc and its dissemination and related histopathology have been, and is still, extensively studied in several different animal models, especially in murine models.

With reference to other cardiovascular risks also associated with CVD and metabolic syndrome, protection against the development of impaired glucose homeostasis and insulin resistance has been reported in animal studies, especially in murine models of metabolic syndrome and type-2 diabetes.

In the search for non-PrPSc markers of scrapie much work has been done in screening mostly brain, but also peripheral lymphoid tissue and serum in different murine models, for different gene expressions, especially different cytokines which have been detected both at mRNA and protein levels [ 11- 16].

However, there are only a few murine models that robustly recapitulate these phenomena, especially after relatively short times (<6 months) of disease development [2], [11], [29], [42].

This increases the interpretative difficulties, especially if one intends to extrapolate the conclusions drawn from murine models to the pathophysiology of the highly complex dorsolateral PFC of primates (Uylings et al. 2003).