Given the cited murine model data showing how directed mutations of stromal cells can lead to myelodysplasia and emergence of AML, we hypothesized that AML patients, at least in some cases, might demonstrate mutations in their BM-MSCs.
From the previous study alone this might have been an idiosyncrasy of the murine model, but data presented here shows a similar response in human cells.
MalarImDB allows comparisons between expression levels in humans, expression levels in murine models, and functional data from experimental treatments in mice.
Investigations on vesiculation during malaria infection in murine models have generated valuable data about the physiopathology of severe malaria [6],[7].
Although deficiencies in NKT cells have been shown to be genetically linked or to precede the development of autoimmunity in murine models of autoimmune disease, data addressing these issues in humans are sparse.
With regard to conflicting interpretations of the sum effect of Wnt signaling on kidney fate, it may be also important to note that loss of cilia appears to be model specific and that we did not observe cilia stunting or β-catenin immune-labeling in other murine models of kidney disease (data not shown).
However, experiments in murine models, extrapolation of clinical data as well as passive administration of pooled immune- γ-globulins (OmriGam), containing a significant titer of neutralizing Abs, before and after infection, showed an important role of the humoral immune response in controlling viremia and prevent viral dissemination.
Data from murine models of sepsis suggest that sFlt-1 may have a protective role in this disease, as sFlt-1 administration reduced VEGF-mediated vascular permeability and mortality [43].
However, we have published data from murine models to indicate the contrary [ 10].
Data from murine models suggest that GITR blockade may be most effective when combined with melanoma vaccination strategies and not as monotherapy [ 65].
