Sentence examples for murine models characterized from inspiring English sources
10 12 It could already be shown that synthetic FXR agonists protect against the development of aortic plaques formation in murine models characterized by a pro-atherogenic lipoprotein profile and accelerated atherosclerosis.
A murine model characterized by a spontaneous chronic recurrent multifocal osteomyelitis related to a missense mutation of the gene for proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) located on chromosome 18 also exists [ 8].
Recently, we observed that infection site microenvironments in the lung of IA murine models are characterized in part by hypoxia [ 6, 7].
While several murine models have been characterized which mutate and/or toggle cyclin D1 expression, to date no genetic systems had been generated which assess cyclin D1b function under the endogenous promoter in vivo.
Several reports have examined the pathogenesis of leishmaniasis in murine models aiming to characterize the mechanisms by which Leishmania parasites induce disease [ 1– 5].
We used the murine Treg-depleted G6PI-induced arthritis model, a clinically relevant model characterized by non-remitting and progressive peripheral polyarthritis with loss of joint structure and function [ 21].
A number of murine models of lupus have been characterized, and they include both transgenic constructs and strains with naturally occurring disease (for review, see [ 49- 56]).
The only major toxicity consistently elicited by cytochalasin B is marked immunosuppression, which has been characterized in multiple murine models [ 230, 231].
Consistent with this, livers from PEDF KO mice have a transcriptional profile closely aligned with murine models of hepatocarcinogenesis and human HCC characterized by aberrant Wnt/ β-catenin signaling.
The present study in mouse is the first to identify changes in whole-genome gene expression in the acutely inflamed ileum of two murine models of intestinal inflammation and to characterize the biological relevance related to these changes.
We show that this infection reproduces important aspects of fungal-epithelial interaction previously characterized in vitro, in murine models and in human disease.
