We first investigated the potential functions that RIPK1 could play in liver parenchymal cells during fulminant viral hepatitis by taking advantage of a physiological murine model based on MHV3 infection.
Given the high homology between human and murine Her2/neu [ 30], we propose that our human ECD/Her2 vaccine will also induce cross-reactive CTL against murine Her2/neu, rejecting transplantable tumors expressing murine Her2/neu, thus breaking tolerance against self-Her2/neu, as also proposed in other tumor models based on xeno-vaccinations [ 8, 31].
Ly6Chigh monocytes, the murine correlate of human classical monocytes, drive atherosclerosis in transgenic animal models based on the genetic deletion of apolipoprotein E or the LDL receptor [26,37,45,59-61].
A frequently used murine model is based on the intrarectal administration of TNBS and produced human-like CD and is characterized by Th1-mediated inflammation [ 34].
Another murine model is based on the use of the CaMKII promoter to drive Cre-recombinase expression, achieving a CrT deletion only in postnatal forebrain excitatory neurons.
Preclinical models based on patient-derived xenografts have remarkable specificity in distinguishing transformed human tumor cells from non-transformed murine stromal cells computationally.
We used the murine calvarial osteolysis model based on ultra-high molecular weight polyethylene (UHMWPE) particles in 10 C57BL/6J wild-type (WT) mice and twenty Calca -/- mice.
The relevance of the human genomic data accrued by Biankin et al. [ 41] was also confirmed in a murine pancreatic cancer model based on transposon-mediated mutagenesis [ 43].
Most preclinical reports of the effects of RT in murine models have been based on subcutaneous or intramuscular xenograft tumours.
In the current study, mathematical modelling based on murine experimental data dissects IFN-γ as a cytokine candidate responsible for impaired bacterial clearance, thereby promoting bacterial growth and systemic dissemination during acute IAV infection.
