Our results also suggest that the integration of mutagenesis data and expression network analysis may help to unravel key events in other cancers which disrupt complex developmental programmes, for which murine models are available.
Additionally, in some cases murine models might be available, enabling interpretation of the pathomechanistic impact of impaired function of a particular gene.
These DSG2mt/mt mice expand currently available murine models of desmosome-related dilative cardiomyopathy (DCM) and ARVC [ 18, 33, 47, 65].
Implications and future directions Using zebrafish to probe the genetic, epistatic and environmental factors underlying NF1 pathology offers several important advantages over currently available murine models.
The options for future experimentation regarding the fitness of fluoroquinolone-resistance mutations in Salmonella are in vitro and ex vivo cellular systems or the available murine models.
Only two murine models of CCDS1 are available so far, and they have only been analyzed at the behavioral and neurochemical level.
Currently available murine models for MM include immunocompetent mice, such as the 5TMM series [ 12, 13] and genetic models of MM [ 14, 15], or immunocompromised mice, namely, NOD/SCID [ 16], SCID-hu [ 17, 18], and NOG [ 19, 20].
Currently available murine models for MM include immunocompetent mice, such as the 5TMM series [ 48, 49] and genetic models of MM [ 50- 52], or immunocompromised mice, namely NOD/SCID [ 13- 23], SCID-hu [ 53- 56], and NOG [ 24, 25, 38, 57].
This phenotype is reminiscent of the CCDS1 symptomatology, therefore the main output of the present report is an increase in the number of available murine models for this disorder as claimed in the article.
This aspect is understudied in human VL although several reports are available in murine models for both CL and VL.
