Sentence examples for murine model where from inspiring English sources

While we have previously evaluated and utilized this score in rat models of sepsis [5, 41], this is the first description of its use in a murine model, where mortality and serum biochemical markers of organ failure correlated with clinical severity (data not shown).

Adapted from a murine model where mechanisms of stress-induced reactivation of colitis was studied [12], we recently showed that repeated combined acoustic and restraint stress, which is a model of severe stress involving physical restraint and emotional stress, induces depression-like alterations and immunosuppression in BALB/c mice.

Thus, in an experimental murine model, where infection is induced with a low-dose aerosol, infected lungs show a very limited and transient localised increase in the cellularity between the epithelia and the lamina propria rather than granulomatous lesions in the first three weeks post-infection despite the fact that the bacillary load increases up to 105 CFU[35], [35].

These changes were greatest in the combination FK506-hydrocortisone murine model where the fungal burden was also highest.

The compound was used in an L. infantum murine model where it exhibited high efficacy upon intraperitoneal dosing at 20 mg/kg/day for 4 weeks.

Further confirmation of the role of the Hh pathway comes from a murine model where SMO is deleted in the hematopoietic compartment during embryogenesis.

This phenomenon explains why apoptotic cell therapy promotes heart allograft survival in murine models where the direct pathway plays a dominant role in acute rejection [37], [38].

A second possibility is suggested by murine models where autoantibody responses have been linked to weak CD8+ cytolytic T cell responses [69].

Evidences of the role of Treg cells as suppressors of T cell responses in malaria were initially demonstrated in murine models, where these cells have been associated with increased [16], [17] or delayed [18], [19] parasite growth.

Similar observation was reported earlier with L. donovani infection in murine models where it was found that IL-4 and IL-10 might act in concert to ensure logarithmic parasite growth [32].

Further evidence for the role of Tregs in tumor-specific immunosuppression is seen in murine models where depletion of Tregs promotes an effective antitumor response[ 5].