Sentence examples for murine model when from inspiring English sources
In a murine model, when attenuated S19 and virulent 2308 strains were compared to genetically engineered strains, including: (1) a knock-out mutant of 2308 (ΔeryCD), (2) a naturally reverted S19 strain (ery resistant), and (3) strainrain transformed with the wild type ery operon, there was no direct correlation between erythritol metabolism and in vivo colonization [18].
We have previously suggested a combination antibiotic-antitoxin approach to anthrax therapy and for the first time demonstrated an increased efficacy of ciprofloxacin treatment in a murine model when it was combined with a caspase inhibitor administration [ 22].
Ribeiro et al. [ 12] described a high protection rate (80%) in a murine model when using an iron acquisition-deficient mutant obtained with the same methodology employed to develop the CP09 mutant, showing that C. pseudotuberculosis live attenuated mutants can be promising tools for protection against caseous lymphadenitis.
They also illustrate the need for researchers to be careful when choosing among murine models when planning to study SCA3 disease pathogenesis.
The higher expression of phenotypic characteristics related to virulence by S. brasiliensis can explain its higher virulence in murine models, when compared to S. schenckii [ 32].
To improve the immunogenicity of the five-plasmid mixture, a sixth plasmid encoding human granulocyte macrophage-colony stimulating factor (hGM-CSF) was added, based on enhanced protection in murine models when a plasmid encoding murine GM-CSF was combined with other plasmids encoding malaria antigens.
In tolerogenic DC-based therapies, immature, maturation-resistant, or alternatively-activated DC are generated in vitro by different culture, pharmacologic or genetic methods and then administered i.v. into graft recipients, with optimal results in murine models when the DC are administered 7 days prior to transplantation.
The lower weight loading (9%-NP) of docetaxel was found to have a superior pharmacokinetic profile and enhanced efficacy in a murine cancer model when compared to that of a higher docetaxel loading (20%-NP).
The induction of high levels of anti-TNF antibodies reduced the number of metastases reaching and establishing themselves in the lungs as well as their size in the B16F10 murine melanoma model when compared to mice immunised with PBS in CFA.
Inhibition or genetic ablation of DPPIV/CD26 showed promising engraftment-promoting effects in several murine models especially when limited numbers of donor cells were used [25].
Many adjuvants that hold promise for induction of CD8 T-cell responses based on murine model studies fail when evaluated in human clinical trials.
