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In a murine model we investigated mode-of-action, efficacy, and safety of a homologous RENCA cell-based vaccine.
Furthermore, in a murine model, we were able to show the safety, immunogenicity, and therapeutic activity of this optimized mRNA.
Using a murine model, we show that direct application of liposome-complexed siRNA mediates gene-specific silencing in cervicovaginal and rectal mucosa.
Furthermore, using the same murine model, we have shown that antiviral therapy controls virus replication and prevents lung fibrosis [9].
Using a murine model, we assessed the immunogenicity of a recombinant VACV that was engineered to lack a known virulence determinant of VACV, the N1L gene.
In a much more complex in vivo system, murine model, we confirmed that CFTR is a negative regulator of the NFκB mediated response and absence of CFTR results in an inherent defect in IκB-NFκB mediated innate immune response.
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To produce a tool for cellular and molecular studies in genetically engineered murine models, we defined the optimal culture conditions for primary cultures of articular chondrocytes from newborn mice (C57Bl/6).
Based on results obtained in murine models we have explored the CD95-mediated activation-induced cell death (AICD) strategy to selectively deplete alloreactivity in human donor T lymphocytes in vitro.
To allow an in vivo evaluation of the potency of CD137L-DCs in murine models we aimed at generating murine CD137L-DCs.
To examine the role of established tumor murine models we first used WT and KO mice derived from WT (S1)×KO (S4) crossmating.
Similar to murine models, we show here that FoxP3+ human cells are located in the medulla.
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