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Therefore, we used a murine model to test the hypothesis that HBP causes acute lung injury (ALI) in vivo.
We used a murine model to assess the evolving biomechanical properties of tissue engineered vascular grafts (TEVGs) implanted in the arterial circulation.
Briefly, we used a pediatric and neonatal murine model to identify the effects of CS/SHS exposure on proteostasis/autophagy and HIF-1α expression as a potential mechanism for development of BPD-like pulmonary dysfunction in the pediatric population.
Second, Chan and colleagues used a murine model to show that lymphoma cells in the vitreous could migrate through the retina and gather between the neural retina and the RPE [4].
Here, we used a genetically engineered murine model to measure Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) activity and pro-inflammatory cytokine secretion to test the hypothesis that oral consumption of whole grape formulation reduces inflammatory signaling in the body.
Our data caution extrapolation of findings about F. tularensis within the murine model to human infection.
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Thus, only little advantage has been taken of numerous genetically engineered murine models to study excitation through the cardiac conduction system of the mouse.
We urge caution in applying findings in murine models to septic patients, both with regard to our understanding of pathophysiology and the failure to translate preclinical efficacy into successful clinical trials.
In the meantime, we suggest that caution be applied in extrapolating findings in murine models to septic patients, both with regard to our understanding of pathophysiology and the failure to translate preclinical efficacy into successful clinical trials.
In these studies we used a series of genetically modified Pkd1 and Pkd2 murine models to investigate the cause of embryonic lethality in mutant embryos.
We used several murine models to determine how the increased inflammatory response observed in the absence of PPARα affects tumor growth and metastasis.
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