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We have developed animal models utilizing mice with severe combined immunodeficiency (SCID) which will accept human tumor cells or murine model systems of syngeneic and allogeneic transplantation.
Knowledge of factors that regulate HSC activity is derived largely from murine model systems, with serial transplantation often considered a "gold standard" to assess longevity and self-renewal of HSCs.
Changes in the expression of several genes in response to arsenic treatment in our model had previously been demonstrated by other investigators to also induce NTDs in murine model systems.
Using murine model systems, we here demonstrate that TH positively regulates serum Se and selenoprotein P (Sepp) levels.
Retention of other viruses such as HIV in a replication-competent state within the light zone of GCs has been reported and the next step will require the development and interrogation of murine model systems [22].
CD44 was previously used alone [14] and in conjunction with other cell surface markers to sort CSC from various epithelial malignancies, in both human and murine model systems [15], [16], [17], [18], [19], [20], [21].
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We used the immortalized cell line mIMCD-K2, a murine model system for the renal inner medullary collecting duct, to study the direct effects of adenosine on NaCl transport across the inner medullary collecting duct epithelium with an Ussing chamber system.
In this study, a plasmid expressing a tumor antigen incorporated into the signal peptide of human IL-2 was tested as a DNA vaccine in a murine model system.
This study investigates the changes in the nanostructure of bone following the application of a degrading WZ21 Mg implant (2 wt% Y, 1 wt% Zn, 0.25 wt% Ca and 0.15 wt% Mn) in a murine model system over the course of 15 months by small angle X-ray scattering.
In this study, we evaluated the immunomodulatory effect of a genetic variant of the third domain of ovomucoid (GMFA) which showed reduced IgE binding with egg allergic patient's sera in comparison to the native form of the third domain of ovomucoid (DIII) in a murine model system.
Retrovirus-mediated expression of the protein provides a murine model system for further analysis of the disease.
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