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Herein, we characterized a murine model recapitulating the formation of Mikulicz cells in lungs and identified them as atypical inflammatory monocytes specifically recruited from the bone marrow upon K. rhinoscleromatis infection in a CCR2-independent manner.
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On the basis of these findings, we conclude that the murine model recapitulated biologic features of the subset of NSCLC adenocarcinoma patients with poor clinical outcomes.
These murine models recapitulate the salient features of human NEB mutation, including severe muscle weakness, impaired force generation and histopathological changes including reduced thin filament length and the presence of nemaline rods and bodies.
We hypothesized that mast cells mediate pelvic pain directly and examined pain behavior using a murine model that recapitulates key aspects of IC.
Here we examine mechanisms of pelvic pain in an established murine model that recapitulates key aspects of IC, including lamina propria mast cell accumulation and pelvic pain [11], 12, 13.
Due to the difficulty of attaining ample specimens from early stage patients, preliminary study of early stage PC diagnosis through PBMC expression analysis may be first carried out in a spontaneous PC murine model which recapitulates the preneoplastic and early neoplastic processes seen in human PC as a proof of concept [31], [32].
31 Following these advances, in a recent study on a murine model that recapitulates the main clinical signs of HGPS, vivo-morpholino ASOs were able to reverse many of the phenotypical alterations seen in these mice.
Genetic ablation of TBX5 in murine models imposingly recapitulates the human phenotype [ 12].
The potential of gold silica SERS nanoparticles combined with a hand-held Raman scanner to provide image-guided surgical resection of GBMs is demonstrated in a transgenic murine model that closely recapitulates human brain tumors.
"The mouse model recapitulates what is seen in human disease.
This model recapitulates highly aggressive claudin-low (mesenchymal) TNBC chemoresistant breast cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com