In murine models, however, thrombocytopenia and platelet antagonists decrease tumor metastases indirectly supporting a plausible role for COX-1 platelet inhibition in cancer prevention and treatment [ 13, 14].
Studies in murine models, however, suggest that adiponectin may mitigate the severity of arthritis [ 54, 55] - suggesting either that different isoforms of adiponectin exist or that different signalling cascades may be activated in different tissues.
The human oesophageal stratified squamous epithelium is maintained through an exquisite balance between proliferation and terminal differentiation. 1 Most of the current knowledge on tissue homeostasis and injury repair is based on murine models; however, there are fundamental differences between mouse and human oesophagus.
A study using a murine xenograft model however has its inherent limitations.
Recent studies in murine asthma model, however, suggest that PARP1 inhibition may have anti-inflammatory effects by regulating IL-5 production (Datta et al, 2011).
Disease severity is reduced by NF- κB inhibition in the mdx mouse, a murine DMD model; however, therapeutic targeting of NF- κB remains problematic for patients because of its fundamental role in immunity.
Contrary to the 'just enough' model, however, the murine Fbxw7 +/− genotype did promote intestinal tumorigenesis, whether alone or on an Apc mutant background, whereas we predict that this genotype causes insufficient functional derangement to promote human tumorigenesis.
However, a murine model is also necessary to evaluate antiviral agents, vaccines, and immune response.
Most of these murine models of lupus, however, are associated with diffuse B-cell hyperactivity or defects in the clearance of apoptotic material or both.
