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However, the entire epitope mapping of OVA in a murine model has not been completed yet.
Murine model has been extensively employed to understand the role of Th1 responses in M. tuberculosis infection and vaccine-induced protection [10], [11].
Importantly, this murine model has been very useful in assessing the clinical efficacy of potential new drugs for NB like the angiogenesis inhibitor HPMA copolymer-TNP-470 caplostatincaplostatin) [24] and the ornithine decaroboxylase inhibitor α-difluoromethylornithine [26].
Taken together, these results demonstrate how the murine model has allowed us to finely dissect two classes of events affecting GAS sociomicrobiology: those related to reversible transcriptional adaptation and those irreversibly caused by the covS mutation in AP bacteria.
The traditional murine model has proven useful in the quest for understanding the virulence mechanisms of the Bcc [13], [14], [15], [16], but the search is on for more cost-effective alternatives and for somewhat less controversial widescreen models with faster generation time.
Murine model has been considered a good experimental system for studying the pathological mechanisms of food allergy [ 11, 12].
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Previous studies performed on the same murine model have shown that AQP4 plays a pivotal role in modulating astrocytic function [17], [18] and preserving the blood brain barrier [19].
Mimiviruses can induce infection in a murine model, have had antibodies detected in patients with pneumonia, and can replicate in murine and human phagocytes (11, 12 ).
Recent investigations in a murine model have demonstrated that mast cells can have a critical role in the generation of inflammation within the joint.
Studies in a murine model have suggested S. aureus clearance is T-cell mediated and happens via an IL-17A-dependent recruitment of neutrophils [ 48].
Immunohistochemical studies of the early events of infection in a murine model have shown that the amoebae induce intense mucus secretion and an inflammatory reaction in the nasal cavity [ 6].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com