In previous studies from our laboratory we characterized the immunogenicity of Nef from CRF12_BF and BF variants, evaluating the characteristics of the cellular immune response in primary HIV infected persons [33], and in a murine model expressing the protein from DNA and MVA vectors [24].
Our observation that only aggressive and bone metastatic mammary carcinoma cell lines of our murine model express this receptor is consistent with these studies.
P McLaughlin (Groningen, the Netherlands) investigated the consequences of targeting monoclonal antibodies to normal and tumour tissue in a transgenic murine model expressing human EpCAM.
A significant reduction in β-catenin translocation to the nucleus, which is indicative of impaired Wnt signaling functions, has been detected in transgenic murine models expressing familial AD mutations [ 36].
The R6/2 transgenic mouse model for HD is a well-established murine model that expresses mutant human Huntingtin exon1 having 150 CAG repeats.
In the present study, we intended to utilize a DNA vaccine encoding the ST antigen to generate an antitumor effect in a murine tumor model expressing ST.
Similar to the human samples, in the murine model, tumor vessels expressed JAM-C at EC junctions, as indicated by expression of the EC junctional marker VE-cadherin (Fig. 1 B).
The T70I sod1 zebrafish model offers the advantage over current murine models of expressing the mutant Sod1 protein at a physiological level, as occurs in humans with ALS.
We have generated the first BRI2 Danish Knock-In (FDDKI) murine model of FDD, expressing the pathogenic decamer duplication in exon 6 of the BRI2 gene.
In a murine model only CXCR4 expressing, but not CXCR4-deficient CT-26 colon carcinoma cells grew into macrometastases; nonetheless both cell types were able to colonise livers and lungs after injection (Zeelenberg et al, 2003).
