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In the murine model established with subcutaneous injection of Jurkat cells, xenograft tumors formed at the site of injection in all mice.
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In the present study we demonstrate that TLR2 plays an important role in the pathogenesis of bacteria-enhanced diet-dependent atherosclerosis in the ApoE+/− murine model, establishing a key link between atherosclerosis and immune defense against foreign pathogens and/or endogenous inflammatory ligands.
Data from studies of the effect of those antibodies in murine models established a contribution of complement activation to the placental inflammation, TNF production, neutrophil accumulation and fetal death that mimics the events that sometimes occur in lupus patients with antiphospholipid antibodies [ 51, 52].
We investigated the effects of THC in a murine model of established atherosclerosis.
Accordingly, in a murine model of established intracerebral tumor, vaccination-induced immunity in the setting of MA TMZ-but not lymphodepletive, NMA TMZ-led to significantly prolonged survival.
To address this question, a murine model was established in order to assess the in vivo effects of anti-INA on CNS (Figure 4A).
A bioluminescent murine model was established to assess tumor metastasis in vivo.
In a preclinical murine model of established arthritis, a depleting murine anti-LTα antibody had efficacy comparable to that of anti-TNF-α antibodies, whereas an LTβR/Ig blocker had no effect [ 6].
This new method was validated in an established murine model of microbead-induced optic neuropathy.
Using an established murine model of CDI, stability and efficacy of frozen and lyophilized FMT product was studied at time points from 2 months to 15 months.
This gulf in our understanding of immunity to malaria may be addressed by novel application of an established murine model of immune regulation of blood stage infection.
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