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To ensure that the different topical formulations that were to be used for application in the murine model did not impact the MICs, the activity of GaCi formulated in HEC was also tested and shown to be identical to the unformulated results found in Table 1 (data not shown).
However, although there are multiple mouse models carrying different mutations in the murine GALNS homolog [Tomatsu et al., 2003; Tomatsu et al., 2005a; Tomatsu et al., 2007; Tomatsu et al., 2008; Tomatsu et al., 2010], mouse and human catabolism of KS differs and the murine model did not develop the dysostosis phenotype of Morquio A [Tomatsu et al., 2010].
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CONCLUSION: Bacterially induced labor in the murine model does not require IL-1 signaling.
Second, the osteolysis murine model does not fully reproduce the loading conditions of a prosthetic implant subjected to loosening.
Although murine models do not fully recapitulate human infection, they are commonly used to evaluate EHEC vaccines and the immune/protective responses elicited in the host.
Murine models do not equate to pre-eclampsia in women, but they can replicate many of the pre-eclampsia symptoms.
Emerging results in the quantity and distribution of neuropathological features will be discussed in the context of human disease, although the present murine models do not entirely recapitulate these findings at present.
Even the canonical murine models do not fully reflect human infections: for example, mice have a different commensal microbiome, and typical risk factors in humans include compromised immunity, underlying diseases and old age, which are not represented in the murine model.
However in a different rabbit model and also murine model, this did not hold true [ 52, 53].
Therefore, interaction of F. tularensis with autophagy is specific to the murine model but does not apply to the human host.
The genetic models of PD, established by inducing mutations associated with familial forms of PD, are of limited value because most of the murine genetic models do not display the characteristic loss of DA neurons observed in PD, as they are still at an early stage of this disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com