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This study was performed using the MPS-I murine model described in [ 21] bred into a NOD-SCID-IL2Rγ (NSG) background [ 22].
Though renal tumors are highly vascularised and could represent one novel target for RAS blockers, only one murine model described that ACE-Is prevent the development of distant metastasis [ 14].
The TSE's are primarily a disease of the nervous system and there is much published evidence of temporal pathological events where one would expect changes in protein expression, for example, in the murine model described in this study, changes in the synapses and in the dendrites are present at an early stage of disease [ 18, 23, 24].
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The murine AI model described here may also provide a useful tool to aid in our further understanding of ER stress in the future.
Most of the experiments in vivo examining TR cell suppression have been based on the murine IBD model described above and have, as with Tr1 cells, flagged the importance of IL-10 and TGF-β.
This constitutes a major difference with the invasion-independent murine mammary tumour model described above.
To induce a moderate level of inflammation, we used a standardized murine TNBS colitis model (described in [ 25]).
We also greatly appreciate the expertise of Eran Andrechek in developing the mouse model described in this manuscript and providing technical support related to the murine experiments.
Other studies of murine models have described the crucial role of ΔNp73 in survival of neurons in the CNS [ 37, 38].
An elegant murine model has been described recently that facilitates independent or simultaneous inactivation of the linked c-IAP1 and c-IAP2 genes [ 25].
This reproduced the previously described murine model of rosacea [3].
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