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Previously, we have demonstrated that one of the initial effects of mutated β-catenin is the increase of PSCs in the ACP murine model compared with control pituitaries.
The results of the present study showed that etoposide entrapped in camel milk phospholipid liposomes shows greater anticancer activity against fibrosarcoma in a murine model compared to free etoposide or etoposide entrapped in DPPC-liposomes.
While CG's activity against HPV dominated in the CG-GRFT mix, the benefits of the use of this combination were supported by the significant decrease in HSV-2 infection (P = 0.0352) in the murine model compared to the decrease achieved by the use of CG or GRFT alone.
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Thereby, the distance of AuNP to the membrane tended to be larger in diseased animals of both murine models compared to the healthy mice, though not statistically significant.
Additionally, a mouse/human chimeric IgE (MOv18 IgE) specific for the human ovarian cancer antigen folate binding protein (FBP) demonstrated superior anti-tumor activity in murine models compared to a mouse/human chimeric IgG1 with the same variable regions (MOv18 IgG1) [ 47, 48].
This targeted liposomal l-OHP formulation showed efficient antitumor activity in a murine tumor model, compared with l-OHP-containing PEG-coated "neutral" liposomes.
Interestingly, combination therapy using AMD3100 and nilotinib led to significantly prolonged survival in this murine leukemia model compared with treatment with only nilotinib (P<0.05).
They further demonstrated that exposure to lipopolysaccharide (LPS) evoked a greater immune response in a viable murine CFTR knockout model compared to wild-type animals.
Using this murine model, we compared the pathogenesis of B. pseudomallei infection after introducing the bacterium by IV, intraperitoneal (IP), intranasal, oral, and subcutaneous (SC) routes of infection.
Human chimeric MOv18 IgE has shown superior efficacy in two murine xenograft models compared with MOv18 IgG1.
Our results indicate that attenuation of mutants might be less pronounced in the embryo model compared to systemic murine infections and that complementation might not sufficiently rescue virulence phenotypes in all cases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com