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Recent advances in identifying the bone marrow-derived stem cell as the cell of origin of Helicobacter-induced gastric cancer in the murine model are discussed and interpreted in the context of human disease, and implications for future treatment are discussed.
Inferences from the murine model are not entirely appropriate as the initial environment encountered by transmigrating monocytes is quite different to that in humans.
PURPOSE: We have reported previously that tumors expressing wild-type epidermal growth factor receptor (EGFR) in a murine model are sensitive to the EGFR tyrosine kinase inhibitor gefitinib, whereas tumors expressing mutant EGFR variant III (EGFRvIII) are resistant.
This demonstrates that the changes associated with development of severe nephritis in the murine model are also relevant to human lupus nephritis.
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Murine model was developed, and results were encouraging.
The disease is associated with haploinsufficiency and a murine model was obtained by engineering mice that express a single Endoglin allele.
However, the preliminary assessment of the efficacy of the hydrogels on the murine model is inconclusive, which warrants further investigation and molecular engineering.
A murine model was used to assess whether siRNA treatment is also effective in vivo.
Subsequently, a murine model was developed by INA immunization that bears pronounced cognitive dysfunction which mimics NPSLE.
Subsequently, a murine model was developed by INA immunization that resulted in pronounced cognitive dysfunction that mimicked features of NPSLE.
The mortality rate in the CLP induced septic shock murine model is higher in the older mice [34], owing to a more severe and fatal systemic injury.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com