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Another study in a murine model also showed that susceptibility to TB could be reduced by avoiding overload of iron using LTF [ 23].
A recent study using a murine model also found that platelets promote breast cancer metastases in a time-dependent manner; however, NK cell destruction of circulating tumor cells was not affected by platelets [ 28].
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Evidence from murine models also showed the difference in basic immune responses between male and female [1].
Evidence from murine models also demonstrates a central role in islet proliferation for both CDKN2A and CDKN2B[ 29, 29].
Evidence from murine models also supports an immunoregulatory role for NK cells in modulating other immune cell responses (Fig. 2b).
To explore whether the effects of estrogen and statins that were observed in the murine models also occur in people, we studied incidence of hospitalized pneumonia associated with the use of estrogen and statins in a population-based case-control study based on medical databases in Denmark.
Despite the expression profile and the phenotypic resemblance, murine models also present limitations such as their relatively long development time and expensive and labor-intensive maintenance, laborious genome editing and, specifically for PXE, a relatively slow onset of the disease [ 65].
This demonstrates that the changes associated with development of severe nephritis in the murine model are also relevant to human lupus nephritis.
However, a murine model is also necessary to evaluate antiviral agents, vaccines, and immune response.
were equally efficient in our murine model, we also used an equal dose of netrin-1 i.v. and netrin-1 inh. in this porcine model.
In vitro models include cell lines derived from primary IBC tumours; a xenograft murine model has also been developed [ 3, 16].
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