Sentence examples for murine malaria models from inspiring English sources

Immune response against circumsporozoite protein (CSP) of Plasmodium berghei, a major surface protein on the sporozoite, confers protection in various murine malaria models.

While the host parasite relationship in humans has been difficult to determine, the pliability of murine malaria models has enabled valuable contributions to the understanding of the pathogenesis of disease.

While murine malaria models are invaluable for basic laboratory testing, they may not accurately predict human vaccine immunogenicity or efficacy.

In preclinical animal models, OZ439 exhibited a prolonged exposure profile resulting in improved efficacy relative to arterolane, artesunate and other comparator antimalarials in murine malaria models (11).

Finally, we make use of two murine malaria models to demonstrate that a short exposure to high levels of CQ is able to induce parasite DV permeabilization in vivo and that this procedure reduces parasite viability.

However, traditional inhibitors of the polyamine pathway aimed at these proteins have cytostatic effects with curative rates only achieved in combination with polyamine analogues in murine malaria models [ 8].

The murine malaria model parasite Plasmodium berghei is the genetically most amendable Plasmodium species and allows full access to the entire life cycle in vivo.

We used a lethal murine malaria model with P. berghei ANKA, a rodent malaria parasite.

Data from a murine malaria model has shown that vaccination with MSP119, another blood-stage antigen, followed by infection with P. yoelii, leads to apoptosis of MSP1-specific memory B cells [21].

In a murine malaria model, DNA immunization followed by recombinant MVA boosting induced a protective CTL response, whereas the vaccines in reverse order was not, nor was either of the vaccines by themselves [49].

The dose-response efficacy studies were conducted in the Plasmodium berghei murine malaria model, and the relationship between dose and efficacy (i.e., reduction in parasitemia) was examined.