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The origin of basal cells in the murine lung is uncertain.
miRNA expression in the allergically inflamed murine lung is regulated by genetic loci that are smaller in effect size compared to mRNA eQTL and often act in trans.
Very recent work showed that TSLP expression in the murine lung is influenced by peptidyl-propyl isomerase (PIN1), an important regulator of survival-promoting and proinflammatory cytokines in T-cells.
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To determine if the differences in GSNO-R activity in the adult murine lung were due to changes in protein expression, Western blot analysis was performed (Figure 1C).
The bronchioles of the murine lung are lined by a simple columnar epithelium composed of ciliated, Clara, and goblet cells that together mediate barrier function, mucociliary clearance and innate host defense, vital for pulmonary homeostasis.
Increased MIP-2 in murine lung was observed after high volume ventilation by Dr Li and co-workers [ 7].
This is supported by the fact that phenotypes observed for the PCP effectors Intu and Fuz in the mucociliary epithelium of the frog and Fltp in the murine lung are strikingly similar (Park et al., 2006, 2008).
In addition, CT imaging of murine lungs is an attractive adjunct to histologic analysis for the confirmation and staging of pneumonia.
One of several signaling events described to lead to alternative macrophage activation in response to CMP challenge in murine lungs is CCL2 release from epithelial cells (Roy et al. 2012).
Human and murine lungs were placed in 4% paraformaldehyde and processed for paraffin embedding.
Frozen human and murine lungs were cut (5 µm) and fixed in acetone/methanol (1∶1).
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