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Together with findings from studies of comparative B. pseudomallei gene expression in humans and murine hosts, such findings are becoming more clinically relevant.
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Immunization of murine hosts against specific B. burgdorferi antigens, such as DbpA [46], [47], OspC [48] and OspA [49] can elicit production of borreliacidal antibodies, and thus confer protective host immunity possibly by killing spirochetes in vivo when administered prior to spirochete infection.
The approach circumvents some of the current hurdles with rodent xenografts, such as those related to availability of sufficient patient material or challenges in optimizing murine hosts to enhance engraftment.
The v-abl oncogene of the Abelson murine leukemia virus (A-MuLV) is known to efficiently transform NIH/3T3 fibroblasts in vitro and to cause an acute lymphosarcoma in susceptible murine hosts.
The differences discovered between human and murine TAP binding specificity were shown to correlate with differences in the ability to predict epitope recognition in murine hosts.
Nevertheless, these findings indicate that C. jejuni colonizes the intestinal tract of murine hosts exhibiting defective innate or immunoregulatory responses.
Here we show that BbCRASP-2 function is also dispensable for infectivity of the murine hosts or in feeding ticks.
Thus, comparable to murine hosts and epithelial models, C. glabrata induces overall less proinflammatory cytokines than C. albicans.
In nature, however, this density of subadult ticks on murine hosts is unlikely (16).
Moreover, interspecies differences such as incompatibilities in receptor-ligand interactions between the human tumor cells and murine host microenvironment can impair the species-specific pathways occurring during human cancer progression and metastasis (Khanna and Hunter, 2005; Rangarajan and Weinberg, 2003).
Such tolerant anti-Ehrlich ascites tumour sera, when tested in vivo, were toxic for the tumour and relatively innocuous for the murine host.
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