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The resulting nanoclusters were able to identify regions of defective vasculature in an ischemic murine hindlimb using MRI with iron doses that were 5 10 fold lower than those typically used in preclinical studies.
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Recently, researchers demonstrated improved neovascularization in a murine hindlimb ischemia model using an FGF-based hydrogel delivery system [ 70].
The purpose of this study was to evaluate the role of MKP-1 in neovascularization in vivo and identify associated mechanisms in endothelial cells.We used murine hindlimb ischemia as a model system to evaluate the role of MKP-1 in angiogenic growth, remodeling, and arteriogenesis in vivo.
Such animals execute voluntary gait modification of fore- and hindlimbs using visual and other sensory cues [5].
The murine hindlimb ischemia preparation is a model of PAD, and is useful for testing new therapies.
In this study, we show for the first time the use of an injectable alginate hydrogel for controlled delivery of lentivectors in the skeletal muscle of murine hindlimb.
The murine hindlimb ischemia model exhibits tissue remodeling including revascularization in part due to angiogenesis.
In a severe murine hindlimb ischemia model, HGF delivery from the affinity-binding system improved tissue blood perfusion and induced mature blood vessel network formation.
Hydrogels with QPQGLAK crosslinks supported prolonged retention of these proteins via heparin within the matrix, stimulating rapid vascular development, and anastomosis with the host vasculature when implanted in the murine hindlimb.
Time-series NIR fluorescence images were obtained after injecting ICG intravenously in a murine hindlimb ischemia model.
Based upon these works, in the present study we transplanted human VPC-derived vascular cells; that is, EC and MC in a murine hindlimb ischemia model.
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