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Human orthologs of the 905 murine genes found to be differentially expressed in ovarian surface epithelium during the estrous cycle [13] were identified using the list of mouse-human orthologous genes available from the Mouse Genome Informatics database (http://www.informatics.jax.org; accessed Sept 2009).
We examined expression levels of canonical NOTCH3 target genes (HES1, HEY1, HEYL) and of 17 potential target genes (PERP, PLN, TBX2, SUSD5, TIMP4, PTP4A3, GRIP2, KCNA5, NRIP2, S1PR3, PGAM2, CDH6, XIRP1, RCAN2, ANGPT4, HP and SORBS2) homologous to murine genes found to be robustly downregulated in caudal distal arteries of Notch3−/− mice (Fouillade et al, 2013).
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Holcomb et al. [1] discovered mouse Fizz3 and human FIZZ3 by searching sequence databases for genes similar to the novel murine gene Fizz1, found in inflammatory zone 1. Kim et al. [2] named a new murine protein as solely adipose tissue-specific secretory factor (ADSF) and Steppan et al. [3] called it resistin for causing resistance to insulin.
With this approach, we found that 845 murine genes display expression downstream of the RefSeq annotation.
We also studied the murine genes Cebpe, Retn and Retnlg, because the latter was found as a regulatory and functional equivalent of human RETN [12].
Muro et al. [ 22] found that about 60% of human and murine genes utilize multiple (on the average, 3-4) polyadenylation sites.
The strongest hypermutation bias of the compared genes was found in Medauroidea, which is even slightly stronger than in the corresponding human and murine genes.
Nonetheless, all existing guidelines have been devised to select effective siRNAs targeting human or murine genes.
Recently, murine Retn was found to be a possibly potential regulator of hematopoiesis in mice shown in the screening results of a set of gene chips which mapped the expression level of murine genes during regeneration of impaired bone marrow (BM) by 5-fluorouracil.
The Affymetrix murine oligonucleotide array (Mu11KSubB) is complementary to ~6,500 murine genes and expressed sequence tags (ESTs).
Differential digital display analysis performed on murine tissues provided a list of 101 potentially oocyte-specific murine genes [ 25- 27].
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