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All murine experiments were performed in accordance with protocols approved by the Institutional Animal Care and Use Committees at University of Nanjing Medical University.

All murine experiments were conducted in compliance with animal protocols approved by the Chinese Academy of Science Institutional Animal Care and Use Committee.

Data from in vivo murine experiments were analyzed using a one-way ANOVA with treatment specified as the main effect.

In this study, all in vivo murine experiments were performed on the C57BL/6 background, where in our hands, 80 100% of wildtype (WT) mice develop symptoms of ECM.

Colon explants cultures from murine experiments were performed as described previously.

H. pylori infection status and H. pylori-induced gastritis in murine experiments were confirmed (data not shown).

Although murine experiments are crucial to advance our knowledge of mechanisms which underlie virus-bacteria interactions, examining all different factors in detail is extremely difficult work.

The selected doses of sorafenib and docetaxel in these murine experiments are associated with plasma concentrations that are similar to those observed in patients receiving sorafenib at 400 mg b.i.d.

Murine BMT experiments were performed as previously described.

Murine BM transplantation experiments were performed as previously described (paper 1).

For comparison of survival in the murine lethal challenge experiments individual experiments were analyzed using the Prism software (Prism for Windows, version 5.01, GraphPad Software), and choosing the Log rank, Mantel Cox test statistical method for testing statistical significance.