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In vivo data from murine experiments showed limited activity at >10 mg kg−1; however, complete cures were not reported.
Our in vitro and in vivo murine experiments showed that In-DOTA-dLVT selectively binds to OTR-positive cells and tumours, and is thus a potentially powerful reagent for the imaging and treatment of OTR-positive cancers.
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Our data reinforce results from murine experiments, showing that exogenous polyamines govern polyamine homeostasis as well as influence the efficacy of DFMO and sulindac.
Following early murine experiments showing that oil-in-water adjuvants, such as Incomplete Freund's Adjuvant (IFA) and Montanide adjuvant, could enhance immune responses to peptide vaccination (Kast et al, 1993), Montanide adjuvant has been used by our group and others in clinical trials (Tsuboi et al, 2004; Rezvani et al, 2008; Maslak et al, 2010; Kuball et al, 2011).
For instance, murine experiments have shown that sunitinib can decrease Treg populations 64; other TKIs are associated with immune system-potentiating effects 65.
In vitro experiments showed that MMP-8 cleaves murine and human IL-10, and tissue from knockout animals showed decreased IL-10 processing.
Previous experiments showed most of the phenotypes induced by murine HOXB9 to be clearly distinct from those induced by Drosophila ABD-B [41].
The pharmacological experiments showed AICD has a good inhibitory effect on murine hepatoma H22-induced tumors.
Preliminary experiments showed that these CD32/CD86-transduced CD32/CD86-transduced were killed by MLEC-PAI-1-Lucivated cells cells were T cells were co-cultured with the reporter cells in the presence of anti-CD3.
The in vivo experiments showed that CA significantly suppressed subcutaneous tumor development and lung metastasis in a murine sarcoma model.
ChIP experiments showed that EWS/FLI1 decreases the amount of Pol II at the promoter of downregulated genes in both murine and human model systems.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com