Then we BLASTed the murine (data not shown) and human (Table 1) enhancers against the same positive databases.
We searched in GenBank genome-related databases, by BLAST, for the presence of murine (data not shown) and human IgH alpha exons (Table 1).
Consistent with murine data, heterozygous mutations and deletions of the SPI1 locus (the human analogue of Sfpi1) have been described in human primary AML, although it is a rare event (55).
These findings are supported by quantitative real-time PCR experiments showing that neuroserpin expression is high, whereas PAI-1 expression is low in both the murine (data not shown) and human brain.
In the case of mast cells, only murine data are available, and we presented miRNAs which were significantly upregulated during MC differentiation or could be activated by Fc ɛRI crosslinking in the case of MCs in Table 2. MiR-223 is significantly downregulated during MC differentiation.
This is consistent with human and murine data demonstrating the requirement for both IL-17RA and IL-17RC subcomponents in the biological effects of IL-17 [33], [33].
However, both this study and the murine data give a value slightly higher and significantly different from the predicted value, although, as with the regression parameters, the two studies were not significantly different from one another (Table 3).
The absence of KLF4 in the basal cell signature is consistent with its action to directly antagonize KLF5, and with murine data that deletion of KLF4 results in basal cell hyperplasia [89].
Our mathematical model provides a quantitative framework for integrating murine data on food intake, body weight, and body fat to help understand the complex dynamic relationships between diet, expenditure, body composition and metabolic fuel selection.
Murine data showing an increase in aneurysm severity and rupture after inhibition of STAT3 signalling or IL-17A blockade further supports this [ 26].
