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Collecting electrophysiological and molecular data from the murine conduction system presents technical challenges.
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Thus, only little advantage has been taken of numerous genetically engineered murine models to study excitation through the cardiac conduction system of the mouse.
Abnormalities in this conduction system often create cardiac rhythm disturbances.
Most animals will have secondary pacemakers in the conduction system of the ventricles trigger the heart to beat when the conduction through the AV node is stopped.
The majority of these cells differentiated into cardiomyocytes and conduction system cells.
The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.
Wu, M., Peng, S. & Zhao, Y. Inducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic mice.
The impulse proceeds through the ventricular conduction system and into specialized conduction tissue in the subendocardial (innermost) layer of the ventricle.
"When a normal heart rate stimulated by electricity exceeds 250 times a minute, the entire conduction system breaks down and the heart goes into cardiac arrest".
Will's research project will address the transcriptional mechanism of the cardiac conduction system using the mouse cardiac conduction system (CCS) reporter line and the response of these CCS cells to injury.
Then he looked for signs of heart block -- damage caused to the electrical conduction system by a stitch piercing an invisible vital nerve.
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