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To further confirm the therapeutic effect of IL-4 and IL-10 gene therapy, we performed qRT-PCR analysis of their expression in TNBS-induced murine colitis tissues.
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Elevated cytokines in both C. rodentium-induced colitis and Helicobacter-dependent colitis are also increased in colon tissue of chemically-induced murine colitis, as well as human IBD biopsies [29] [35].
Separate serum and tissue models were generated for each of the murine colitis models.
To assess the effects of IL-4 or/and IL-10 expression on treatment of TNBS-induced murine colitis, we intraperitoneally injected these plasmids into mice and then detected these transgenic expressions in murine colon tissues using qRT-PCR.
Murthy, S. N. et al. Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin.
Steidler, L. et al. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.
Salh B, Assi K, Templeman V, Parhar K, Owen D, Gomez-Munoz A, et al. Curcumin attenuates DNB-induced murine colitis.
This study was designed to investigate the effects of parthenolide on an experimental murine colitis model.
We induced murine colitis by intrarectal administration of 2, 4, 6-trinitrobenzene sulfonic acid (TNBS).
The three vaccines were evaluated in vivo in 2,4,6-trinitrobenzene sulphonic acid (TNBS -induced chronic murine coliTNBS -induced
We evaluated the contribution of colonic inflammation to osteopenia and its mechanism in a murine colitis model.
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