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This study was designed to investigate the effects of parthenolide on an experimental murine colitis model.
We evaluated the contribution of colonic inflammation to osteopenia and its mechanism in a murine colitis model.
Treatment with a HIF-1α agonist boosts the innate immune response of the intestinal epithelium in a murine colitis model [72].
Furthermore, conditional knockout of HIF-1α expression in intestinal epithelial cells exacerbated barrier injury and resulted in more severe symptoms in a murine colitis model [54].
Based on its anti-inflammatory properties and previous success in colitis studies, we investigated the effects of IFN-β in a murine colitis model.
Murine colitis model induced by Dextran Sulfate Sodium (DSS) is an animal model of IBD that is commonly used to address the pathogenesis of IBD as well as to test efficacy of therapies.
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The expression of CHI3L1 protein clearly was detectable in lamina propria and colonic epithelial cells (CECs) in several murine colitis models and ulcerative colitis and Crohn's disease patients but absent in normal controls.
Separate serum and tissue models were generated for each of the murine colitis models.
All murine colitis models revealed bacteria in contact with the epithelium.
Failure of this protective barrier to separate bacteria from the epithelium is observed in a number of murine colitis models 15, 17.
However, the reduction in the anti-inflammatory bacterium Faecalibacterium prausnitzii, which is observed to occur in many human IBD studies, was not observed in murine colitis models.
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