Sentence examples for murine cells with from inspiring English sources

The tumorigenicity of murine cells with a mutant p53 transcriptional transactivation domain has clarified the importance of p53-regulated gene expression in the mechanism of cancer suppression by p53 [Nat. Genet. 26 (2000) 37].

Murine cells with deletions of the genes Ogg1, Myh, Neil1 and Polß recapitulate the defect of HIV infection in the absence of BER.

In the second cell model, we studied murine cells with a homozygous gene-trap mutation disrupting the LEDGF/p75 locus [42].

The sphere formation assay was also conducted with cells from another xenograft (Figure 5D), sorted to exclude contaminating murine cells with high levels of ALDH expression (see Figure 3).

Here we report studies of lentiviral integration targeting in 1) human cells with intensified RNAi knockdowns of PSIP1/LEDGF/p75, and 2) murine cells with homozygous gene trap mutations in the PSIP1/LEDGF/p75 locus.

Indeed such abnormalities are observed in patients with HGPS or RD as well as in cultured human and murine cells with aberrant lamin A processing pathways [ 10, 11].

In accordance with weak inhibition observed in murine cells treated with glycosides, our results suggest that CPT and Peruvoside utilize different pathways to alter topoisomerase activity.

It was shown that the levels of p19Arf are strongly upregulated in murine cells treated with histone deacetylase inhibitors (HDACis) [30].

Lentiviral and retroviral supernatants were prepared and leukemic human and murine cells infected with viral particles as described.

However, because TLR ligands are expressed on a different set of murine cells compared with human cells, it will be difficult to evaluate the utility of vaccines and adjuvants that elicit innate immunity in the BLT mouse.

We next monitored the recovery of actin following depolymerization using cytochalasin D. Twenty minutes after treatment, we observed delayed and aberrant recovery of the actin cytoskeleton in Bbs4 −/− mutant murine cells compared with controls (Supplementary Material, Fig. S2).