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Studies from murine cells have suggested that nestin may act as a scaffold to control cell functions including apoptosis [23].
Most studies aimed at achieving replication in murine cells have been limited to fibroblast cell lines, but generating an appropriate model requires overcoming blocks to viral replication in primary T cells.
Because murine cells have very long telomeres, they are not believed to undergo intrinsic senescence in normal conditions.
Prior studies of APP processing in murine cells have demonstrated that murine BACE1 preferentially cleaves wild-type mouse APP at the +11 residue of Aβ [ 6].
It is often stated (see also the article by Kim and colleagues [ 1]) that, in contrast to the human cells, murine cells have very long telomeres and a basal telomerase activity.
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Species specificity was confirmed by an in vitro tumor growth assay (TGA) using admixed human ovarian Skov-3 cells and murine MSC (muMSC) in the same 1∶1 ratio used previously to determine whether the murine cells had any significant effect on the xenograft.
The malignant murine cells had arisen by transformation of murine stromal cells during the first subcultures in vitro, possibly caused by a factor produced by the human melanoma cells.
Murine Th2 cells have increased ICOS cell-surface expression compared to Th1 cells [11] and ICOS surface expression levels have been associated with distinct T cell cytokines.
Studies using murine B cells have demonstrated that nuclear localization of NF-κB p52 is sustained for at least 48 72 hours following BLyS stimulation (laboratory observations; [18], [19], [44]).
TCAIM-expressing murine T cells have been shown to be more susceptible to apoptosis [ 38].
In the literature, both human and murine ES cells have well-documented differentiation and replication capacities [ 19, 20].
Related(20)
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