The analysis of dynamical transcriptional response to TGF-β treatment experiments in different human and murine cell systems revealed commonly affected biological processes and pathways, which could be linked to TGF-β1 via network analysis.
Mono-methyl XAA analogues with substitutions at the seventh and eighth positions were the most active in stimulating human leukocytes to produce IL-6 and IL-8; and for inhibition of tube formation by ECV304 human endothelial-like cells, while 5- and 6-substituted analogues were the most active in murine cell systems.
We have previously observed the inability of R167Q HA-pVHL to bind Elongin C in a transgenic murine ES cell system [25].
Consequently, GAT-1 to GAT-3, the high-affinity GABA transporters, seem to be the best candidates for ALA transport in our murine mammary adenocarcinoma cell system.
This finding is also consistent with previous reports that matrix mineralization and proliferation were reduced significantly on textured surfaces compared with smooth surfaces in a murine femoral stromal cell system [ 16].
This murine E1A/ras-transformed cell system has previously been described for its strict p53- or Apaf-1-dependent apoptotic response to treatment with IR and different cytotoxic drugs in vitro and in vivo (Lowe et al, 1993a; Soengas et al, 1999; Zaugg et al, 2001).
Ahn et al. [ 73] used the murine monocytic RAW 264.7 cell system to examine the effect of simvastatin on osteoclasts.
This study presents the differentiation of sensory neurons (SNs) from a human neural progenitor cell line, hNP1, and their functional maturation in a defined, in vitro culture system without murine cell feeder layers.
The antiproliferative and cytotoxic effect of rML alone and in combination with IR was prominent both in the murine genetically defined, oncogene-transformed tumour cell system and in the human p53-mutated colon adenocarcinoma cell line.
In this study, we used a murine lung carcinoma CMT.64 cell line as a model cell system to address this question.
