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The primary aim of this study was to evaluate the influence of a whey protein diet on computationally predicted mechanical strength of murine bones in both trabecular and cortical regions of the femur.
Treatment with PTH also increased bone mineral density of uninvolved murine bones in myelomatous hosts and bone mineral density of implanted human bones in nonmyelomatous hosts.
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We investigated the effects of BA on murine bone cells in vitro and in ovariectomized (OVx) mice.
Curiously, others have shown that the Tie2 receptor is present on HSCs in the quiescent state in adult murine bone marrow; yet, in some of the present experiments we have found that >96% of the primitive CD90+CD45RA− cells purified from CB are quiescent (as assessed in situ by the absence of the proliferation-associated Ki67 protein; data not shown).
Recently, BMP signalling has been implicated in adult murine bone marrow homeostasis in the regulation of niche size and stem cell numbers (Zhang et al, 2003).
We recently demonstrated that hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) is chemotactic to murine bone marrow cells in vitro and involved in pulmonary vascular remodeling in vivo.
The characteristics of the mutant were examined in an in vitro stationary phase model, in response to stresses; in murine bone marrow derived macrophages and in an acute and an immune resistant model of murine tuberculosis.
In this study, therefore, we used murine bone marrow (BM) cells in an in vitro model in an attempt to determine whether topoisomerase inhibitors (camptothecin, etoposide and doxorubicin) induce myelosuppression (BM cell death) and whether novel treatments other than the administration of G-CSF can be used for rescue from myelosuppression.
Experimental RABV replication in murine bone marrow macrophages and in human macrophage like cell lines suggests a mechanism of virus persistence (22 ).
However, a recent study suggests that MIF inhibits osteoclastogenesis, based on the result that MIF inhibits OC formation in murine bone marrow (BM) cultures in the presence of RANKL.
In this study, we have cultured murine bone marrow cells in the presence of IL-4 and GM-CSF to yield high-quality CD11b+ve CD8−veve CD8−ve myeloid mature DCs that express high levels of stimulatory MHC class II molecules, as well as CD80, CD86 and the chemokine receptor CXCR4.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com