Sentence examples for murine asthma model from inspiring English sources

Jaffer OA, Carter AB, Sanders PN, Dibbern ME, Winters CJ, Murthy S et al. Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-beta-mediated collagen production in a murine asthma model.

For example, the inhibition of PI3K p110δ led to reduced PMN-mediated lung inflammation in a murine asthma model [55].

The generation of Th2 type responses in a murine asthma model is also associated with down regulation of TLR2 expression and the concomitant decreased in clearance of M. pneumoniae [22].

GM-CSF, a key cytokine for eosinophil survival and being produced by both Th2 and Th1 cells as well as epithelial cells [29], [30], was also decreased in the Smad7 transgenic mice, consistent with the previous finding that neutralization of GM-CSF with antibodies could attenuate airway hyper-responsiveness in a murine asthma model [31].

According to a murine asthma model, miR-155 isignificantlyly upregulated at intermediate aerosol exposure [ 15].

This study did not examine the inhibition of ROS generation by astragalin in a murine asthma model.

In murine asthma models, Shibata et al. demonstrated that orally administered chitin suppressed the production of Th2 cytokines and IgE [7] and, when used as an adjuvant, chitin caused similar effects as a Th1-promoting adjuvant [8,9].

In keeping with a role for CCR4 on Th2 cells, anti-CCL17 and anti-CCL22 antibodies have both been observed to have efficacy in murine asthma models.

Murine asthma models have been developed to mimic the two major subtypes of asthma, EA and NA.

Hewitt et al. demonstrated decreased airway resistance after methacholine challenge and increased circulating epinephrine in trained as opposed to sedentary murine asthma models [ 35].

We hypothesise that differences in the two major inflammatory phenotypes of asthma; eosinophilic and neutrophilic asthma, will be reflected in the lung protein expression profile of murine asthma models and can be delineated using proteomics of bronchoalveolar lavage (BAL).